Local translation of synaptic mRNAs is a key process for axonal growth, dendritogenesis and synaptogenesis during nervous system development, and for synaptic plasticity in the adult brain.
Relevance of local translation is illustrated by its direct implication in neuronal pathologies as Fragile X (a common intellectual disability disease) and SMA (involving degeneration of motor neurons).
Our lab is interested in elucidating the role of local translation in other diseases characterized by intellectual disability or motor neuron degeneration.
Thus, several molecular and cellular clues point to an impairment of local translation in trisomy 21 (Down’s syndrome) and in amyotrophic lateral sclerosis (ALS).
Using mouse models, our goal is to translate the obtained results to the corresponding human neuronal pathologies.