• Proteomic analysis of synaptoneurosomes highlights the relevant role of local translation in the hippocampus.

I Benito, JJ Casañas, ML Montesinos

Proteomics 2018 Jun 19:e1800005. doi: 10.1002/pmic.201800005. [Epub ahead of print]


  • Local translation of the Down Syndrome Cell Adhesion Molecule (DSCAM) mRNA in the vertebrate central nervous system

ML Montesinos

J Neurogenet 31:223-230 (2017)

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  • Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

Y Andrade-Talavera, I Benito, JJ Casañas, A Rodríguez-Moreno, ML Montesinos

Neurobiol Dis 82:516-525 (2015)


  • Roles for DSCAM and DSCAML1 in central nervous system development and disease

ML Montesinos

Adv Neurobiol 8:249-270 (2014)

  • Editorial: Pharmacological intervention for Down syndrome cognitive deficits: emerging drug targets

ML Montesinos

CNS Neurol Disord Drug Targets 13:6-7 (2014)


  • The Akt-mTOR pathway in Down's syndrome: the potential use of rapamycin/rapalogs for treating cognitive deficits

JA Troca-Marín, JJ Casañas, I Benito, ML Montesinos

CNS Neurol Disord Drug Targets 13:34-40 (2014)



  • Deregulated mTOR-mediated translation in intellectual disability

JA Troca-Marín, A Alves-Sampaio, ML Montesinos

Prog Neurobiol 96:268-282 (2012)


  • An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down’s syndrome

JA Troca-Marín, A Alves-Sampaio, ML Montesinos

J Neurosci 31:9445-9455 (2011)


Commented in "This week in The Journal" (TWIJ article)


  • NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down’s syndrome

A Alves-Sampaio, JA Troca-Marín and ML Montesinos

J Neurosci 30:13537-13548 (2010)


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  • Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation

JA Troca-Marín, A Alves-Sampaio, FJ Tejedor and ML Montesinos

Mol Cell Neurosci 43:308-315 (2010)





Title: Use of rapamycin for the treatment of the cognitive deficits associated with Down's syndrome

Authors: ML Montesinos, JA Troca-Marín, A Alves-Sampaio

Date: 24 June 2010

Patent number: P201000840

WO 2011/161282 A1