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Guest Editor Special Issue:

"Synaptic Plasticity in Health and Disease"

Open now for submission!

More information: link

Deadline: 31 August 2022


SYNAPTIC LOCAL TRANSLATION LAB

Departamento de Fisiología Médica y Biofísica. Universidad de Sevilla

Instituto de Biomedicina de Sevilla (IBiS)

SPAIN


Local translation of synaptic mRNAs is a key process for axonal growth, dendritogenesis and synaptogenesis during nervous system development, and for synaptic plasticity in the adult brain. Relevance of local translation is illustrated by its direct implication in neuronal pathologies as Fragile X (a common intellectual disability disease) and SMA (involving degeneration of motor neurons).


Our lab is interested in elucidating the role of local translation in other diseases characterized by intellectual disability, trisomy 21 (Down’s syndrome) in particular. Using mouse models, our goal is to translate the obtained results to the corresponding human neuronal pathologies.

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Synaptoneurosome preparation

Culture of hippocampal neurons


Microelectrode Array

(MEA)

Memory tests


Barnes maze

Object recognition

Copyrigth ML Montesinos