ML Montesinos CV

1) Academic career:

• Grade in Biology with Special Awards. July 1992. Universidad de Sevilla (Spain).

• PhD cum laude in Biology (Biochemistry and Molecular Biology). October 1997.

Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla).

Subject: Amino acid, ammonium and urea transport systems in cyanobacteria.

Supervisors: Enrique Flores and Antonia Herrero.

2) Professional career:

• November 1997 to September 2003: Postdoctoral Researcher. Ecole Normale Supérieure-CNRS. Alain Prochiantz’s lab (Paris, France).

Positions during that period: Postdoctoral EMBO fellow (1997/99). Associate Researcher CR3 (funded by CNRS, 1999/2000). Postdoctoral fellow from FRM (“Foundation pour la Recherche Medicale”, 2001/01). Assistant Professor (ATER) of Molecular and Cellular Genetics (2001/02). Associate Researcher (funded by Human Frontier Science Program, 2002/03).


-Target genes, cofactors and mode of action of Engrailed homeoproteins during vertebrate CNS development.

-Engrailed-1 homeoprotein: dendritic localization and role in local translation.

• October 2003 to December 2005: “Ramón y Cajal” Investigator, associated to Rafael Fernández-Chacón’s lab. Dpto. Fisiología Médica y Biofísica. Universidad de Sevilla (Spain).

Subject: synaptic proteins involved in neurodegeneration.

• January 2006 to date: Synaptic local translation laboratory Group leader. Dpto. Fisiología Médica y Biofísica. University of Seville.

Positions during that period: “Ramón y Cajal” Investigator until February 2008. From March 2008 to date, Associate Professor of Physiology.

Subject: mRNA transport and local translation in synaptic pathologies.

Research Group affiliated to IBiS (Instituto de Biomedicina de Sevilla).

3) General administrative and organizational experience

Sociedad Española de NeuroCiencia (SENC) Executive Board member (October 2013 to September 2017).

• Chair of the SENC Communication Committee (October 2013 to September 2017).

FENS Communication Committee member (July 2014 to July 2018).

Sociedad Española de Bioquímica y Biología Molecular (SEBBM) Molecular Neurobiology Group Coordinator (October 2015 to July 2019).

• Chair of the Trisomy 21 Research Society (T21RS) Communication Work Group (June 2018-October 2020).

• Academic administrative responsibility as Secretary of the Departmento de Fisiología Médica y Biofísica (Universidad de Sevilla, Spain). February 2010-February 2013.


1) JD Urbano-Gámez, JJ Casañas, I Benito, ML Montesinos

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model

Mol Brain 18:84 (2021)

Open access:

    2) JJ. Casañas, M. González-Corrales, JD. Urbano-Gámez, A. Alvez-Sampaio, JA. Troca-Marín, ML. Montesinos

    CPEB1 is overexpressed in neurons derived from Down syndrome IPSCs and in the hippocampus of the mouse model Ts1Cje

    Mol Cell Neurosci 95: 79-89 (2019)

    3) I. Benito, JJ. Casañas, ML. Montesinos

    Proteomic analysis of synaptoneurosomes highlights the relevant role of local translation in the hippocampus

    Proteomics 18:e1800005 (2018)

    4) Y. Andrade-Talavera, I. Benito, JJ. Casañas, A. Rodríguez-Moreno, ML. Montesinos

    Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

    Neurobiol. Dis. 82:516-525 (2015)

    5) JA. Troca-Marín, JJ. Casañas, I. Benito, ML. Montesinos

    The Akt-mTOR pathway in Down's syndrome: the potential use of rapamycin/rapalogs for treating cognitive deficits

    CNS Neurol. Disord. Drug Targets 13:34-40 (2014)

    6) JA. Troca-Marín, A. Alves-Sampaio, ML. Montesinos

    Deregulated mTOR-mediated translation in intellectual disability

    Prog. Neurobiol. 96:268-282 (2012)

    7) JA. Troca-Marín, A. Alves-Sampaio, ML. Montesinos

    An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down’s syndrome

    J. Neurosci. 31:9445-9455 (2011)

    8) A. Alves-Sampaio, JA. Troca-Marín and ML. Montesinos

    NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome

    J. Neurosci. 30: 13537-13548 (2010)

    9) JA. Troca-Marín, A. Alves-Sampaio, FJ. Tejedor and ML. Montesinos

    Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation

    Mol. Cell. Neurosci. 43:308-315 (2010)

    10) A. Di Nardo, S. Nedelec, A. Trembleau, M. Volovitch, A. Prochiantz and ML. Montesinos

    Dendritic localization and activity-dependent translation of Engrailed1 transcription factor

    Mol. Cell. Neurosci. 35:230-236 (2007)

    11) ML. Montesinos, M. Castellano-Muñoz, P. García-Junco-Clemente and R. Fernández-Chacón

    Recycling and EH-domain proteins at the synapse

    Brain Res. Rev. 49:416-428 (2005)

    12) R. Fernández-Chacón, M. Wölfel, H. Nishimune, L. Tabares, F. Schmitz, M. Castellano-Muñoz, C. Rosenmund, ML. Montesinos, JR. Sanes, R. Schneggenburger and TC. Südhof

    The synaptic vesicle protein CSP-alpha prevents presynaptic degeneration

    Neuron 42:237-251 (2004)

    13) I. Foucher, ML. Montesinos, M. Volovitch, A. Prochiantz and A. Trembleau

    Joint regulation of the MAP1B promoter by HNF3ß/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors

    Development 130:1867-1876 (2003)

    14) ML. Montesinos, I. Foucher, M. Conradt, G. Mainguy, L. Robel, A. Prochiantz and M. Volovitch

    The neuronal Microtubule-Associated Protein 1B (MAP1B) is under homeoprotein transcriptional control

    J. Neurosci. 21:3350-3359 (2001)

    15) G. Mainguy, ML. Montesinos, B. Lesaffre, B. Zevnik, M. Karasawa, R. Kothary, W. Wurst, A. Prochiantz and M. Volovitch

    An induction gene trap for indentifying a homeoprotein-regulated locus

    Nat. Biotechnol. 18:746-749 (2000)

    Highlighted in “This month in Nature Biotechnology”