Lab's Publications


  • Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model 

JD Urbano-Gámez, JJ Casañas, I Benito, ML Montesinos

Mol Brain 14:84 (2021)

Open access:

  • CPEB1 is overexpressed in neurons derived from Down syndrome IPSCs and in the hippocampus of the mouse model Ts1Cje

JJ Casañas, M González-Corrales, JD Urbano-Gámez, A Alves-Sampaio, JA Troca-Marín, ML Montesinos

Mol Cell Neurosci 95:79-85 (2019)

  • Proteomic analysis of synaptoneurosomes highlights the relevant role of local translation in the hippocampus.

I Benito, JJ Casañas, ML Montesinos

Proteomics 18:e1800005 (2018)

  • Local translation of the Down Syndrome Cell Adhesion Molecule (DSCAM) mRNA in the vertebrate central nervous system

ML Montesinos

J Neurogenet 31:223-230 (2017)

  • Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

Y Andrade-Talavera, I Benito, JJ Casañas, A Rodríguez-Moreno, ML Montesinos

Neurobiol Dis 82:516-525 (2015)

  • Roles for DSCAM and DSCAML1 in central nervous system development and disease

ML Montesinos

Adv Neurobiol 8:249-270 (2014)


  • Editorial: Pharmacological intervention for Down syndrome cognitive deficits: emerging drug targets

ML Montesinos

CNS Neurol Disord Drug Targets 13:6-7 (2014)


  • The Akt-mTOR pathway in Down's syndrome: the potential use of rapamycin/rapalogs for treating cognitive deficits

JA Troca-Marín, JJ Casañas, I Benito, ML Montesinos

CNS Neurol Disord Drug Targets 13:34-40 (2014)

  • Deregulated mTOR-mediated translation in intellectual disability

JA Troca-Marín, A Alves-Sampaio, ML Montesinos

Prog Neurobiol 96:268-282 (2012)

  • An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down’s syndrome

JA Troca-Marín, A Alves-Sampaio, ML Montesinos

J Neurosci 31:9445-9455 (2011)


Commented in "This week in The Journal" (TWIJ article)

  • NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down’s syndrome

A Alves-Sampaio, JA Troca-Marín and ML MontesinosJ Neurosci 30:13537-13548 (2010)


Recommended in F1000Prime

  • Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation

JA Troca-Marín, A Alves-Sampaio, FJ Tejedor and ML Montesinos

Mol Cell Neurosci 43:308-315 (2010)


Title: Use of rapamycin for the treatment of the cognitive deficits associated with Down's syndrome

Authors: ML Montesinos, JA Troca-Marín, A Alves-Sampaio

Date: 24 June 2010

Patent number: P201000840

WO 2011/161282 A1